Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease.
Identifieur interne : 000E20 ( Main/Exploration ); précédent : 000E19; suivant : 000E21Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease.
Auteurs : Meike Kasten [Allemagne] ; Lena Kertelge ; Vera Tadic ; Norbert Brüggemann ; Alexander Schmidt ; Joyce Van Der Vegt ; Hartwig Siebner ; Carsten Buhmann ; Rebekka Lencer ; Kishore R. Kumar ; Katja Lohmann ; Johann Hagenah ; Christine KleinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, Depression (complications), Depression (genetics), Depression (psychology), Depressive Disorder (complications), Depressive Disorder (genetics), Depressive Disorder (psychology), Female, Health Status, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (genetics), Parkinson Disease (psychology), Quality of Life (psychology), Questionnaires, Severity of Illness Index.
- MESH :
- complications : Depression, Depressive Disorder, Parkinson Disease.
- genetics : Depression, Depressive Disorder, Parkinson Disease.
- psychology : Depression, Depressive Disorder, Parkinson Disease, Quality of Life.
- Adult, Aged, Female, Health Status, Humans, Male, Middle Aged, Questionnaires, Severity of Illness Index.
Abstract
Quality of life (QoL) is decreased in PD and is linked with depression and anxiety. However, little is known about QoL in monogenic PD. Subjects with mutations in PD genes were recruited from ongoing family and genetic studies (manifesting carriers, n = 23; nonmanifesting carriers, n = 19). For comparison purposes, we included patients with idiopathic PD (IPD; n = 128; early onset, n = 38; late onset, n = 90), healthy controls (n = 127), and data on depressive symptoms of 144 patients with major depression (treated controls). Depression affected 31% of early-onset PD cases, 21% of late-onset cases, and 44% of manifesting carriers of mutations in PD genes, but was rare in the nonmanifesting carriers (7%) and healthy controls (5%). Subjects with Parkinson-associated depression reported fewer feelings of guilt or self-doubt than treated controls, but the occurrence of suicidal ideation was associated with severity of depression only. Social phobia (P = 0.018) and agoraphobia (P = 0.059) were more common in manifesting carriers than in any other group. QoL was decreased in the Parkinson groups, particularly in the early-onset cases (P < 0.001), and QoL correlated with depression in all analyses. In our study, monogenic and IPD cases were comparable in QoL and depression characteristics. The QoL and, possibly, overall prognosis of all PD patients can be improved by appropriate attention and treatment for depression, sleep impairments, and anxiety, even if the treatment of the motor problems cannot be further optimized.
DOI: 10.1002/mds.24999
PubMed: 22550041
Affiliations:
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Le document en format XML
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Kumar</name></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name></author><author><name sortKey="Hagenah, Johann" sort="Hagenah, Johann" uniqKey="Hagenah J" first="Johann" last="Hagenah">Johann Hagenah</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24999</idno><idno type="RBID">pubmed:22550041</idno><idno type="pmid">22550041</idno><idno type="wicri:Area/PubMed/Corpus">000D83</idno><idno type="wicri:Area/PubMed/Curation">000D83</idno><idno type="wicri:Area/PubMed/Checkpoint">000E62</idno><idno type="wicri:Area/Ncbi/Merge">003647</idno><idno type="wicri:Area/Ncbi/Curation">003647</idno><idno type="wicri:Area/Ncbi/Checkpoint">003647</idno><idno type="wicri:Area/Main/Merge">000E52</idno><idno type="wicri:Area/Main/Curation">000E20</idno><idno type="wicri:Area/Main/Exploration">000E20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease.</title><author><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany. Meike.Kasten@neuro.uni-luebeck.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Kertelge, Lena" sort="Kertelge, Lena" uniqKey="Kertelge L" first="Lena" last="Kertelge">Lena Kertelge</name></author><author><name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name></author><author><name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name></author><author><name sortKey="Schmidt, Alexander" sort="Schmidt, Alexander" uniqKey="Schmidt A" first="Alexander" last="Schmidt">Alexander Schmidt</name></author><author><name sortKey="Van Der Vegt, Joyce" sort="Van Der Vegt, Joyce" uniqKey="Van Der Vegt J" first="Joyce" last="Van Der Vegt">Joyce Van Der Vegt</name></author><author><name sortKey="Siebner, Hartwig" sort="Siebner, Hartwig" uniqKey="Siebner H" first="Hartwig" last="Siebner">Hartwig Siebner</name></author><author><name sortKey="Buhmann, Carsten" sort="Buhmann, Carsten" uniqKey="Buhmann C" first="Carsten" last="Buhmann">Carsten Buhmann</name></author><author><name sortKey="Lencer, Rebekka" sort="Lencer, Rebekka" uniqKey="Lencer R" first="Rebekka" last="Lencer">Rebekka Lencer</name></author><author><name sortKey="Kumar, Kishore R" sort="Kumar, Kishore R" uniqKey="Kumar K" first="Kishore R" last="Kumar">Kishore R. Kumar</name></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name></author><author><name sortKey="Hagenah, Johann" sort="Hagenah, Johann" uniqKey="Hagenah J" first="Johann" last="Hagenah">Johann Hagenah</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Depression (complications)</term><term>Depression (genetics)</term><term>Depression (psychology)</term><term>Depressive Disorder (complications)</term><term>Depressive Disorder (genetics)</term><term>Depressive Disorder (psychology)</term><term>Female</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (psychology)</term><term>Quality of Life (psychology)</term><term>Questionnaires</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term><term>Parkinson Disease</term><term>Quality of Life</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Questionnaires</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Quality of life (QoL) is decreased in PD and is linked with depression and anxiety. However, little is known about QoL in monogenic PD. Subjects with mutations in PD genes were recruited from ongoing family and genetic studies (manifesting carriers, n = 23; nonmanifesting carriers, n = 19). For comparison purposes, we included patients with idiopathic PD (IPD; n = 128; early onset, n = 38; late onset, n = 90), healthy controls (n = 127), and data on depressive symptoms of 144 patients with major depression (treated controls). Depression affected 31% of early-onset PD cases, 21% of late-onset cases, and 44% of manifesting carriers of mutations in PD genes, but was rare in the nonmanifesting carriers (7%) and healthy controls (5%). Subjects with Parkinson-associated depression reported fewer feelings of guilt or self-doubt than treated controls, but the occurrence of suicidal ideation was associated with severity of depression only. Social phobia (P = 0.018) and agoraphobia (P = 0.059) were more common in manifesting carriers than in any other group. QoL was decreased in the Parkinson groups, particularly in the early-onset cases (P < 0.001), and QoL correlated with depression in all analyses. In our study, monogenic and IPD cases were comparable in QoL and depression characteristics. The QoL and, possibly, overall prognosis of all PD patients can be improved by appropriate attention and treatment for depression, sleep impairments, and anxiety, even if the treatment of the motor problems cannot be further optimized.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name><name sortKey="Buhmann, Carsten" sort="Buhmann, Carsten" uniqKey="Buhmann C" first="Carsten" last="Buhmann">Carsten Buhmann</name><name sortKey="Hagenah, Johann" sort="Hagenah, Johann" uniqKey="Hagenah J" first="Johann" last="Hagenah">Johann Hagenah</name><name sortKey="Kertelge, Lena" sort="Kertelge, Lena" uniqKey="Kertelge L" first="Lena" last="Kertelge">Lena Kertelge</name><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><name sortKey="Kumar, Kishore R" sort="Kumar, Kishore R" uniqKey="Kumar K" first="Kishore R" last="Kumar">Kishore R. Kumar</name><name sortKey="Lencer, Rebekka" sort="Lencer, Rebekka" uniqKey="Lencer R" first="Rebekka" last="Lencer">Rebekka Lencer</name><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><name sortKey="Schmidt, Alexander" sort="Schmidt, Alexander" uniqKey="Schmidt A" first="Alexander" last="Schmidt">Alexander Schmidt</name><name sortKey="Siebner, Hartwig" sort="Siebner, Hartwig" uniqKey="Siebner H" first="Hartwig" last="Siebner">Hartwig Siebner</name><name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name><name sortKey="Van Der Vegt, Joyce" sort="Van Der Vegt, Joyce" uniqKey="Van Der Vegt J" first="Joyce" last="Van Der Vegt">Joyce Van Der Vegt</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Kasten, Meike" sort="Kasten, Meike" uniqKey="Kasten M" first="Meike" last="Kasten">Meike Kasten</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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